5In addition, the ability to give the drug parenterally means a more reliable NSAID dose ( i.e. , 100% bioavailability in children with an IV cannula in place), compared with traditional perioperative per rectum NSAID, or where oral dosing is inappropriate. 1#**Advantages of parecoxib over other NSAIDs are that it does not impair platelet function, 1gastrointestinal ulceration is less likely, 1and it does not induce hypersensitivity reactions in patients who have NSAID-induced urticaria or angioedema. ![]() 4The adverse effects of parenteral parecoxib in adult clinical trials are similar to those for NSAIDs, with serious adverse effects such as acute renal failure, Stevens-Johnson syndrome, and hypersensitivity reactions including anaphylaxis and angioedema occurring at low incidence. 3When used in conjunction with opioids perioperatively, COX-2 specific inhibitors were opioid sparing and increased patient satisfaction. 1In adults, it has been shown to be as effective or more effective than the older NSAIDs, 2and also more effective than placebo. It is administered parenterally to adults as a single 40-mg dose for the management of acute postoperative pain. ![]() PARECOXIB is a nonsteroidal antiinflammatory drug (NSAID) that specifically inhibits the enzyme cyclooxygenase-2 (COX-2).
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